PKA and AMPK Signaling Pathways Differentially Regulate Luteal Steroidogenesis

LKB1 and AMPK differentially regulate pancreatic b-cell identity

Fully differentiated pancreatic b cells are essential for normal glucose homeostasis in mammals. Dedifferentiation of these cells has been suggested to occur in type 2 diabetes, impairing insulin production. Since chronic fuel excess (“glucotoxicity”) is implicated in this process, we sought here to identify the potential roles in b-cell identity of the tumor suppressor liver kinase B1 (LKB1/ST...

Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta - Arrestins to Regulate Downstream Signaling Pathways

Contrasting effects of prolactin on luteal and follicular steroidogenesis.

To determine whether prolactin affects both luteal and follicular production of testosterone and oestradiol, pseudopregnant rats, either intact or hypophysectomized on day 8, were injected daily between days 8 and 9 with 1.5 i.u. human chorionic gonadotrophin (hCG), 250 micrograms prolactin or a combination of both. Control rats were given vehicle. On day 9, blood was obtained from the ovarian ...

Signaling pathways that regulate cell division.

Cell division requires careful orchestration of three major events: entry into mitosis, chromosomal segregation, and cytokinesis. Signaling within and between the molecules that control these events allows for their coordination via checkpoints, a specific class of signaling pathways that ensure the dependency of cell-cycle events on the successful completion of preceding events. Multiple posit...

Mitochondria regulate autophagy by conserved signaling pathways

Thank you for submitting your manuscript for consideration by The EMBO Journal. It has now been seen by three expert reviewers, whose comments are copied below. As you will see, all three reviewers find your results suggesting a regulatory link between mitochondria and autophagy upon amino acid starvation potentially interesting. However, especially referees 1 and 2 also raise a number of subst...